Fig. 11.

Effects of glibenclamide on hCFTR and mCFTR currents in whole oocytes. Families of TEVC currents in the absence (control, left) and presence (right) of 100 μM extracellular glibenclamide for hCFTR (A) and mCFTR (B). The voltage protocol included a holding potential V_M = −30 mV, then membrane potential stepped to potentials ranging from V_M = −140 mV to +80 mV in 20-mV increments with a period of 75 ms at each voltage. C: summary of the fractional change in hCFTR and mCFTR current at V_M = +80 mV and −100 mV. #P < 0.01 compared with hCFTR at V_M = +80 mV; n = 4–5 for each condition.