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Full activation of mCFTR required high PKA concentration. Representative macropatch currents of mCFTR recorded in the inside-out mode with symmetrical 150 mM Cl− solution under standard conditions (1 mM MgATP + 127.6 U/ml PKA) (A) and high-PKA conditions (1 mM MgATP + 638 U/ml PKA) (B), via a ramp protocol applied every 5 s as in Fig. 2.
