Fig. 1.
Ozone (O3)-induced airway hyperresponsiveness (AHR) is attenuated in Rho-associated coiled-coil-forming kinase (ROCK)1- and ROCK2-haploinsufficient mice. Wild-type (WT), ROCK1+/−, and ROCK2+/− mice were exposed to O3 (2 ppm for 3 h) or to room air and airway responsiveness was measured 24 h later. Newtonian resistance (Rn; A), the coefficient of lung tissue damping (G; B), the coefficient of lung tissue elastance (H; C), and lung resistance (RL; D). Results are means ± SE of data from 5 to 12 mice/group. *P < 0.05 vs. air-exposed mice; #P < 0.05 vs. WT O3-exposed mice; +P < 0.05 vs. ROCK1+/−.