Fig. 2.
Effect of ROCK1- and ROCK2-haploinsufficient mice on factors contributing to O3-induced AHR in WT mice. Bronchoalveolar lavage (BAL) concentrations of IL-17A (A), TNFα (B), osteopontin (C), hyaluronic acid (HA; D), and pulmonary mRNA abundance of Grpr (E) and in WT, ROCK1+/−, and ROCK2+/− mice exposed to O3 (2 ppm for 3 h) or air and studied 24 h later. Results are means ± SE of data from 4 to 11 mice/group. *P < 0.05 vs. air, #P < 0.05 vs. WT mice with same exposure, and +P < 0.05 vs. ROCK1+/− mice with same exposure.