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Effect of ROCK1 and ROCK2 haploinsufficiency on O3-induced increases in BAL chemokines and growth factors. BAL KC (A), monocyte chemoattractant protein-1 (MCP-1; B), granulocyte colony-stimulating factor (G-CSF; C), and MIP-3α (D) in WT, ROCK1+/−, and ROCK2+/− mice exposed to O3 (2 ppm for 3 h) or air and studied 24 h later. Results are means ± SE of data from 4 to 11 mice/group. *P < 0.05 vs. air; #P < 0.05 vs. WT mice with same exposure; +P < 0.05 vs. ROCK1+/− mice with same exposure.
