Table 1. Patient characteristics of published clinical series on transanal TME.
| Series | N | Age (y)a | Gender | BMI (kg/m2)a | Tumor location (cm)a | Neoadjuvant CRT | Operative technique | Transanal platform | Operating time (min)a | Final TNM stage (n) | Number of lymph nodes collecteda | TME quality | Margins (n) Distal margina Circumferential margina |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sylla et al 2010101 | 1 | 76 | F | 20 | 6 cm from AV | Yes | LA | Rigid metal (TEO; Karl Storz Endoscopy-America, Inc., El Segundo, CA) | 270 | ypT1N0 | 23 | Complete | Negative |
| Chen et al 2010103 | 1 | 47 | M | 22 | 5 cm from AV | Yes | LA | Custom-made | 290 | pT3N2 | 25 | Complete | Negative |
| Tuech et al 2011109 | 1 | 45 | F | 20 | 3 cm from DL | No | LA | Rigid single port (Endorec; Apside Medical; La Talaudiere, France) | 300 | pT1sm3N0 | 15 | Complete | Negative |
| Zorron et al 2012112 | 2 | 54, 73 | M (1), F (1) |
NR | 6, 8 cm from AV | No | LA | Colonoscope, single port (Triport; Olympus America, Southborough, MA) | 390, 410 | pT3N1M0 (2) | 11, 12 | Complete | Negative |
| Dumont et al 201243 | 4 | 66.8 (60–76) | M (4) | 23.4 (22.4–24.5) | 5.3 (4–7) cm from AV | Yes | LA | Single port (Gelpoint; Applied Medical, Rancho Santa Margarita, CA) | 360 (270–460) | NR | 16 (8–22) | Complete | Negative 22.5 mm (10–40) 7.4 mm (1.5–15) |
| Lacy et al 2013106 | 3 | 73 (71–75) | M (1), F (2) |
21.7 (16–25) | 9.7 (9–10) cm from AV | Yes (2), No (1) |
LA | Single port (Gelpoint; Applied Medical) | 143 (125–155) | pT1N0M0 (1), pT3N0M0 (2) | NR | Complete | Negative |
| Velthuis et al 2013110 | 5 | 69.4 (63–79) | M (3), F (2) |
NR | 6 (5–8) cm from AV | Yes | LA | Single port (SILS, Covidien, Mansfield, MA) | 178.2 (160–194) | ypT0N0 (1), ypT2N0 (2), ypT3N0 (1), ypT3N1 (1) | 13.4 (11–17) | Complete | Negative |
| Lacy et al 2013104 | 20 | 65 (44–77) | M (11), F (9) | 25.3 (19–33) | 6.5 (2–15) cm from AV | Yes (14), No (6) | LA | Single port (Gelpoint, Applied Medical) | 234.7 (150–325) | high-grade dysplasia (2), stage I (4), stage II (7), stage III (6), stage IV (1) | 15.9 ± 4.3b | Complete | Negative 2.6 cm (0.7–5) 1.8 cm (0.5–3) |
| Rouanet et al 2013108 | 30 | 65 (43–82) | M (30) | 26.0 (21.0–32.4) | < 5 cm from AV (n = 20), 5 to 10 cm from AV (n = 10) | Yes (29), No (1) | LA | Rigid metal (TEO; Karl Storz Endoscopy-America, Inc.) | 304 (120–432) | pT1 (1), pT2 (8), pT3 (18), pT4 (3); pN0 (14), pN1 (13), pN2 (3) |
13 (8–32) | Complete | Negative (26), positive (4). 9 mm (3–40) 7 mm (0–17) |
| Sylla et al 201384 | 5 | 48.6 (36–63) | M (3), F (2) |
25.7 (22–28) | 5.7 (4–10) cm from AV | Yes (2), No (3) | LA | Rigid metal (TEO; Karl Storz Endoscopy-America, Inc.) | 274.6 (214–423) | pT0N0 (1), pT1N0 (1), pT2N1 (1), ypT2N0 (2) | 33 (16–53) | Complete | Negative 3.6 cm (0.8–10) 0.73 cm (0.2–1.1) |
| Leroy et al 2013107 | 1 | 56 | F | NR | Mid-third of rectum | No | P | Rigid metal (TEO; Karl Storz Endoscopy-America, Inc.) | 190 | Adenoma with low-grade dysplasia | 16 | Complete | NR |
| Zhang et al 2013111 | 1 | 48 | F | 20 | 7 cm from AV | NR | P | Single port (PPH; Ethicon Endo-surgery, Inc., Cincinnati, OH) | 300 | pT3N1M0 | 12 | Complete | Negative |
| Atallah et al 2013102 | 20 | 57 (36–73) |
M (14), F (6) | 24 (18–41) |
5 (1–9) cm from AV | Yes (17), No (3) | LA (11), RA (6), OA (3) | Single port (Gelpoint, Applied Medical) and Single port (SILS, Covidien USA) | 243 (140–495) |
ypT0N0 (5), ypT0N2 (1), ypT2N0 (3), ypT3N0 (4), ypT3N1 (2), ypT3N2 (3), ypT4N0 (2) | 22.5 (9–51) | Complete (11), near complete (6), incomplete (2) | Negative (18), positive (2) |
| Chouillard et al 201482 | 16 | 57.7 (34–81) | M (6), F (10) |
27.9 (21–38) | Mid- or low-rectal tumors | NR | LA (6), P (10) |
Single port (SILS, Covidien USA) | 265 (155–440) |
pTyN0 (1), pT1N0 (3), pT2N0 (3), pT2N1 (1), pT3N0 (3), pT3N1 (3), pT3N2 (1), pT4N0 (1) |
17 (12–81) | Complete | Negative |
| Overall | 110 | 61.5 (34–82) | M (74), F (36) | 25.8 (16–41) | < 5 cm from AV (n = 41), 5 to 10 cm from AV (n = 49), > 10 cm from AV (n = 3) | Yes (75), No (18) | LA (89), RA (6), OA (3), P (12) |
— | 265.6 (120–495) | pT0 (10), pT1 (8), pT2 (20), pT3 (42), pT4 (6), N0 (66), N1–2 (40) | 17.9 (8–81) |
Complete (101), near complete (6), incomplete (2) | Negative (103), positive (6) |
Abbreviations: AV, anal verge; CRT, chemoradiation therapy; DL, dentate line; F, female; LA, laparoscopic assisted; M, male; NR, not reported; OA, open-assisted; P, pure NOTES; RA, robotic assisted; TME, total mesorectal excision; TNM, tumor-node-metastasis.
a
Given as mean (range) for series with n ≥ 3.
b
Data reported as mean ± standard error of the mean.