Table 1.
Baseline characteristics
| NRT (n=106 759) | Bupropion (n=6557) | Varenicline (n=51 450) | |
|---|---|---|---|
| Age (years) | 40·4 (13·6) | 37·7 (11·1) | 38·1 (11·5) |
| Female sex | 55 345 (52%) | 3172 (48%) | 24 686 (48%) |
| Socioeconomic status* | 3·2 (1·4) | 2·9 (1·3) | 3·0 (1·3) |
| Chronic obstructive pulmonary disease | 12 112 (11%) | 427 (7%) | 4140 (8%) |
| Diabetes | 7415 (7%) | 229 (3%) | 2511 (5%) |
| Peptic ulcer disease | 3334 (3%) | 136 (2%) | 1243 (2%) |
| Renal disease | 4618 (4%) | 170 (3%) | 1457 (3%) |
| Rheumatological disease | 3001 (3%) | 106 (2%) | 1059 (2%) |
| Cancer | 4311 (4%) | 159 (2%) | 1449 (3%) |
| Alcohol misuse | 8713 (8%) | 321 (5%) | 2932 (6%) |
| Previous ischaemic heart disease | 6098 (6%) | 175 (3%) | 1791 (3%) |
| Previous cerebral infarction | 3477 (3%) | 97 (1%) | 852 (2%) |
| Previous heart failure | 854 (1%) | 19 (<1%) | 186 (<1%) |
| Previous peripheral vascular disease | 1354 (1%) | 42 (1%) | 412 (1%) |
| Previous arrhythmia | 2335 (2%) | 85 (1%) | 659 (1%) |
| Previous depression | 40 255 (38%) | 2215 (34%) | 16 242 (32%) |
| Previous self-harm | 12 043 (11%) | 610 (9%) | 4621 (9%) |
Data are mean (SD) or n (%). NRT=nicotine replacement treatment.
*
Townsend Index: 1 (lowest level of deprivation) to 5 (highest level of deprivation).41