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. 2015 Oct 6;5:14694. doi: 10.1038/srep14694

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(a) A bioactive pure compound showed a single peak in HPLC profile (PDA detection 190–400nm). (b) The candidate compound showed greater inhibition of FREP1 binding to iRBC lysate as the compound concentration increased. (c) The candidate pure compound (8 μg/mL) significantly inhibited P. falciparum infection. (d) The candidate pure compound’s inhibition of P. falciparum infection in mosquitoes displayed a dose-dependent pattern. N: the number of mosquitoes for each treatment; μ: the average number of oocysts per midgut; PR: infection prevalence in mosquitoes.