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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Trends Pharmacol Sci. 2015 Oct;36(10):628–635. doi: 10.1016/j.tips.2015.07.002

Figure 1.

Figure 1

Effects of NicVAX® on smoking behavior: Panel A: Seven day point prevalence abstinence rates in smokers with high (top 30% based on AUC) and low (bottom 70%) antibody titers compared with placebo injections over 52 weeks. Panel B: Percentage of patients exhibiting end of study abstinence (8 weeks of continuous abstinence, weeks 45-52), grouped by antibody levels. Panel C: Time required to achieve 8 weeks of sustained abstinence before week 46 and continuous abstinence through to week 52 stratified by antibody titer (see Panel A). Ab, antibody, AUC, area under the curve. From reference [6], with permission.