Figure 4.

Rule modulated neurons signal rule change. (A–C) baseline subtracted neural activity for preferred (black) and non-preferred (gray) rule blocks with inset bar plots comparing neural firing during pre-cue and cue epochs between rule representations. (A) In first two trials of a rule block, neuronal activity is significantly higher during cue epoch for preferred rule. (B) In the next eight trials, neural activity for preferred rule increases compared to the early trials, and is significantly higher for preferred rule during both the pre-cue epoch and cue epoch. (C) In the last ten trials, neural activity for rules has significantly decreased compared to the middle eight, though it remains significantly higher for pre-cue and cue epochs compared to non-preferred rule blocks. (D) Correlation of firing rate during the cue epoch with percent correct, showing a significant negative correlation between neural activity and percent correct for the preferred rule block. (E) Unlike during preferred rule blocks, firing rate and percent correct for the non-preferred rule block demonstrates no significant correlation. Significance denoted of at least p < 0.05 with asterisk *.