Table 3.
Measurements of the 24 h ambulatory blood pressure and office blood pressure in the total study group during the 6-week dietary supplementation with quercetin or placebo* (Mean values and standard deviations)
| Quercetin (n 68) | Placebo (n 68) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Endpoint | Mean change | P intra-group | Baseline | Endpoint | Mean change | P intra-group | P inter-group | Treatment difference | |||||||||
| Mean | sd | Mean | sd | Mean | sd | comparison | Mean | sd | Mean | sd | Mean | sd | comparison | comparison | Mean | sd | ||
| 24 h ABP monitoring | ||||||||||||||||||
| Systolic BP (mmHg) | 133·3 | 10·2 | 132·4 | 9·0 | −0·9 | 7·3 | 0·329 | 132·5 | 8·4 | 132·4 | 9·6 | −0·1 | 6·0 | 0·848 | 0·460 | −0·8 | 9·1 | |
| Diastolic BP (mmHg) | 82·0 | 8·5 | 81·4 | 7·6 | −0·7 | 5·3 | 0·304 | 81·4 | 7·1 | 80·9 | 8·5 | −0·4 | 4·5 | 0·425 | 0·711 | −0·2 | 6·8 | |
| MAP (mmHg) | 99·5 | 8·7 | 98·6 | 7·5 | −0·9 | 6·1 | 0·227 | 98·8 | 7·0 | 98·4 | 8·3 | −0·4 | 4·7 | 0·520 | 0·977 | −0·5 | 7·7 | |
| Heart rate (beats per min) | 74·3 | 8·2 | 76·3 | 8·2 | +2·0 | 5·3 | 0·003 | 74·5 | 9·8 | 75·1 | 8·7 | +0·7 | 5·9 | 0·372 | 0·189 | +1·3 | 8·1 | |
| Nocturnal dip in systolic BP (%) | 11·0 | 6·6 | 11·3 | 5·7 | +0·3 | 6·1 | 0·726 | 10·7 | 5·6 | 12·0 | 4·8 | +1·3 | 6·5 | 0·105 | 0·368 | −1·1 | 9·5 | |
| Nocturnal dip in diastolic BP (%) | 15·9 | 7·1 | 16·9 | 6·8 | +1·0 | 6·4 | 0·217 | 16·0 | 6·7 | 17·5 | 6·2 | +1·5 | 7·3 | 0·101 | 0·669 | −0·6 | 10·6 | |
| Day-time (06.00–22.00 hours) | ||||||||||||||||||
| Systolic BP (mmHg) | 136·6 | 10·6 | 135·7 | 9·4 | −0·9 | 7·6 | 0·347 | 135·5 | 8·5 | 136·1 | 9·7 | +0·6 | 6·2 | 0·440 | 0·172 | −1·6 | 9·2 | |
| Diastolic BP (mmHg) | 85·0 | 8·7 | 84·5 | 7·9 | −0·5 | 5·6 | 0·457 | 84·3 | 7·2 | 84·2 | 8·6 | −0·0 | 4·7 | 0·932 | 0·538 | −0·5 | 6·9 | |
| MAP (mmHg) | 102·5 | 8·8 | 101·8 | 7·9 | −0·8 | 6·4 | 0·315 | 101·4 | 7·1 | 101·7 | 8·4 | +0·3 | 4·9 | 0·640 | 0·257 | −1·1 | 7·8 | |
| Heart rate (beats per min) | 76·2 | 8·7 | 78·2 | 8·6 | +1·9 | 5·6 | 0·006 | 76·7 | 10·5 | 77·5 | 9·2 | +0·7 | 6·4 | 0·367 | 0·202 | +1·3 | 8·4 | |
| Night-time (22.00–06.00 hours) | ||||||||||||||||||
| Systolic BP (mmHg) | 121·4 | 11·7 | 120·3 | 10·4 | −1·1 | 9·0 | 0·322 | 120·9 | 10·5 | 119·6 | 9·8 | −1·3 | 9·1 | 0·238 | 0·921 | +0·2 | 14·0 | |
| Diastolic BP (mmHg) | 71·4 | 9·2 | 70·1 | 8·0 | −1·3 | 6·4 | 0·106 | 70·8 | 8·7 | 69·4 | 8·5 | −1·4 | 6·4 | 0·085 | 0·946 | +0·8 | 9·9 | |
| MAP (mmHg) | 88·5 | 9·9 | 87·0 | 8·0 | −1·5 | 7·4 | 0·093 | 88·1 | 9·1 | 86·7 | 8·5 | −1·4 | 7·5 | 0·139 | 0·911 | −0·2 | 11·5 | |
| Heart rate (beats per min) | 66·9 | 8·7 | 69·2 | 8·8 | +2·4 | 6·6 | 0·004 | 67·4 | 9·8 | 68·1 | 9·1 | +0·7 | 7·3 | 0·459 | 0·203 | +1·7 | 10·7 | |
| Office BP | ||||||||||||||||||
| Systolic BP (mmHg) | 144·4 | 16·8 | 146·9 | 17·2 | +2·5 | 10·7 | 0·063 | 143·9 | 14·4 | 143·8 | 17·4 | −0·1 | 10·9 | 0·937 | 0·171 | +2·6 | 15·3 | |
| Diastolic BP (mmHg) | 98·2 | 11·3 | 97·2 | 9·7 | −1·0 | 8·5 | 0·338 | 97·3 | 10·0 | 96·1 | 11·0 | −1·2 | 7·3 | 0·166 | 0·863 | +0·2 | 11·5 | |
| MAP (mmHg) | 113·6 | 12·5 | 113·8 | 11·6 | +0·2 | 8·5 | 0·879 | 112·8 | 10·7 | 112·0 | 12·6 | −0·9 | 7·7 | 0·361 | 0·472 | +1·0 | 11·6 | |
| Heart rate (beats per min) | 64·6 | 7·9 | 65·7 | 8·3 | +1·1 | 5·5 | 0·112 | 63·9 | 9·1 | 65·6 | 8·0 | +1·6 | 6·4 | 0·040 | 0·598 | −0·5 | 8·2 | |
ABP, ambulatory blood pressure; BP, blood pressure; MAP, mean arterial pressure.
*
The two groups did not differ significantly with regard to any of the variables at baseline (paired Student’s t tests or Wilcoxon signed-rank tests).