Table 3.
Comparison of demographic and clinical characteristics of wounded warriors requiring RRT for AKI managed in the National Capital Region on the basis of in-hospital mortality
| Demographic Features | Survived (n=40) | Died (n=11) | P Value |
|---|---|---|---|
| Age at injury (y) | 25±5 | 28±6 | 0.10 |
| Sex (male) | 39 (98) | 11 (100) | >0.99 |
| Race | |||
| White | 26 (65) | 8 (73) | 0.73 |
| Black | 8 (20) | 0 (0) | 0.19 |
| Other | 6 (15) | 3 (27) | 0.39 |
| Injury features | |||
| Type of injury (IED) | 26 (65) | 9 (81.8) | 0.47 |
| Units of PRBCs downrangea | 24 (0–159) | 26 (0–200) | 0.32 |
| Hospital days in National Capital Region | 90±70 | 16±7 | 0.001 |
| Estimated surgeries until death or discharge | 13±9 | 7±3 | 0.04 |
| Amputation | 27 (68) | 9 (82) | 0.47 |
| Maximum CPK (units/L)b | 15,053 (155–200,000) | 11,574 (691–1,900,000) | 0.95 |
| Clinical features of AKI | |||
| Presumed cause of AKI | ATN 39 | ATN 11 | >0.99 |
| Rhabdo 29 | Rhabdo 7 | ||
| Other 1 | Other 0 | ||
| Days from injury to RRT | 8±11 | 7±7 | 0.78 |
| Serum creatinine at initiation | 6.01±2.96 | 3.66±1.07 | 0.01 |
| AKI integer scorec | 20 (14–37) (n=40) | 24 (19–34) (n=9) | 0.04 |
| Probability of mortality from integer scorec (%) | 23 (6–96) (n=40) | 44 (18–91) (n=9) | 0.04 |
| Indications for dialysis | |||
| Hyperkalemia | 27 (68) | 8 (73) | >0.99 |
| Volume overload | 21 (53) | 4 (36) | 0.50 |
| Acidosis | 17 (43) | 6 (55) | 0.51 |
| Azotemia | 22 (55) | 4 (36) | 0.32 |
| Other | 2 (5) | 0 (0) | >0.99 |
| Days on RRT | 20±11 | 12±11 | 0.04 |
| RRT treatments per week | 4.7±1.1 | 6.0±1.2 | 0.001 |
| RRT modality | |||
| iHD | 39 (98) | 11 (100) | >0.99 |
| SLEDD | 20 (50) | 5 (46) | >0.99 |
| CRRT | 8 (20) | 5 (46) | 0.12 |
| CRRT as initial RRT modality | 6 (15) | 4 (36) | 0.19 |
Data are presented as mean±SD, median (range), count (%), or as otherwise indicated. IED, improvised explosive device; PRBCs, packed red blood cells; CPK, creatine phosphokinase; ATN, acute tubular necrosis; iHD, intermittent hemodialysis; SLEDD, slow low efficiency daily dialysis; CRRT, continuous RRT.
a
Data were transformed using a square-root transformation before t test.
b
Data were transformed using a log transformation before t test.
c
Wilcoxon rank-sum test.