Table 3.
Associations between urinary excretion of EGF receptor ligands and measures of autosomal dominant polycystic kidney disease severity at baseline
| Variable | HB-EGF Excretion | EGF Excretion | TGF-α Excretion | |||
|---|---|---|---|---|---|---|
| Correlation Coefficient | P Value | Correlation Coefficient | P Value | Correlation Coefficient | P Value | |
| mGFR (ml/min) | −0.39 | 0.05 | 0.63 | <0.001 | 0.78 | <0.001 |
| ERPF (ml/min) | −0.37 | 0.07 | 0.64 | <0.001 | 0.75 | <0.001 |
| TKV (ml) | 0.39 | 0.05 | −0.57 | 0.002 | −0.44 | 0.02 |
| Albumin excretion (mg/24h) | 0.40 | 0.05 | −0.38 | 0.06 | −0.31 | 0.13 |
| IgG excretion (μg/24h) | 0.18 | 0.40 | −0.23 | 0.26 | −0.02 | 0.94 |
| KIM-1 excretion (μg/24h) | 0.14 | 0.49 | −0.15 | 0.47 | −0.03 | 0.89 |
| HFABP excretion (μg/24h) | 0.44 | 0.03 | −0.60 | 0.002 | −0.32 | 0.12 |
| NGAL excretion (μg/24h) | 0.10 | 0.63 | −0.32 | 0.12 | −0.46 | 0.02 |
| MCP-1 excretion (μg/24h) | 0.21 | 0.31 | 0.18 | 0.39 | 0.40 | 0.05 |
HB-EGF, heparin-binding EGF; TGF-α, transforming growth factor alpha; mGFR, measured GFR; ERPF, effective renal plasma flow; TKV, total kidney volume; KIM, kidney injury molecule; HFABP, heart-type fatty acid–binding protein; NGAL, neutrophil gelatinase–associated lipocalin; MCP, monocyte chemoattractant protein.