Table 1. Demographic, clinical and neuropsychological data in normal control (NC), mild cognitive impairment (MCI) and Alzheimer’s disease (AD) subjects.
| NC(n = 27) | MCI(n = 27) | AD(n = 35) | p value | |
|---|---|---|---|---|
| Gender (M/F) | 16/11 | 13/14 | 12/23 | 0.143 |
| Age (year) | 69.2 ± 6.5 | 73.8 ± 7.8 | 72.4 ± 8.5 | 0.090 |
| MMSE | 28.9 ± 1.0 | 26.8 ± 1.8a | 19.7 ± 4.1a,b | <0.001 |
| CDR | 0 | 0.5 | 1.3 ± 0.5a,b | <0.001 |
| AVLT-Immediate Recallc | 5.9 ± 1.1 | 4.6 ± 1.5 | 2.6 ± 1.6a,b | <0.001 |
| AVLT-Delay Recallc | 5.8 ± 2.0 | 3.1 ± 2.0a | 0.6 ± 1.2a,b | <0.001 |
| ApoE e4 carrier (%)d | 15% | 38% | 64% | — |
| Head Motion | 0.25 ± 0.27 | 0.16 ± 0.10 | 0.30 ± 0.27 | 0.084 |
MMSE, mini-mental state examination; CDR, Clinical Dementia Rating; AVLT, auditory verbal learning test, ApoE, apolipoprotein E.
Chi-square was used for gender comparisons, One-way ANOVA with Bonferroni post hoc test was used for age, and neuropsychological tests comparisons.
aSignificant compared to NC.
bSignificant compared to MCI.
cThree AD subjects refuse to continue this test.
d66 (NC = 20, MCI = 21, AD = 25) of the 89 subjects have ApoE genotype.