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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Nat Genet. 2015 Aug 10;47(9):1067–1072. doi: 10.1038/ng.3378

Figure 3.

Figure 3

Y/RTCA analysis and estimated mutation load of highly APOBEC-mutated cohorts. (a–f) Only samples significantly enriched for mutations at TCA (q < 0.05) are shown. Samples with YTCA mutation to RTCA mutation ratio statistically different from random (q < 0.05) are binned by quartile of TCA enrichment and plotted as filled symbols. Samples with YTCA > RTCA enrichment are considered A3A-like. Those with RTCA > YTCA enrichment are A3B-like. p-values from χ2 test for trend are shown. Samples significantly enriched at TCA, but with YTCA vs. RTCA ratio not statistically different from random (q > 0.05), are plotted as unfilled, gray-bordered symbols and not included in tests for trend. (g) The minimal estimated number of TCA mutations attributable to APOBEC mutagenesis, for A3A- (pink) or A3B-like (green) samples in each cohort, and for all six cohorts combined, are shown along with medians and Kolmogorov-Smirnov p-values. See Online Methods for analytical details.