Table 4.

Main effects of timing of treatment initiation and treatment on carotid gene expression and mean expression ratio of E2/control in carotid gene expression.

	P Values			Ratio (E2 /control) of Early Menopause cohort		Ratio (E2/control) of Late Menopause cohort
	Menopause	Treatment	Interaction	Mean Ratio	P	Mean Ratio	P
CD68	0.007	0.001	0.130	0.16	0.002	0.48	0.106
CD163	0.223	0.032	0.046	0.40	0.008	0.97	0.900
CD83	0.002	0.012	0.206	0.18	0.015	0.56	0.307
CD3	0.884	<.001	0.339	0.22	<.001	0.36	0.003
CD4	0.015	<.001	0.812	0.38	0.014	0.34	0.001
CD8	0.300	<.001	0.460	0.22	0.001	0.33	0.002
CD25	0.002	0.001	0.877	0.14	0.017	0.16	0.008
FoxP3	0.002	0.028	0.492	0.50	0.061	0.70	0.222
CCR6	<.001	0.016	0.306	0.68	0.351	0.39	0.008
NCAM-1	0.262	0.026	0.079	0.47	0.010	0.91	0.696
ACTA2*	0.568	0.467	0.574	1.37	0.400	1.04	0.892
ColI	<.001	<.001	0.092	0.29	<.001	0.59	0.047
MCP-1†	0.095	0.001	0.593	0.26	0.011	0.37	0.025
IFN-γ‡	0.465	0.004	0.112	0.31	0.004	0.71	0.308
TNFα	0.001	<.001	0.090	0.19	<.001	0.50	0.050
IL-2‡	0.000	0.048	0.760	0.52	0.138	0.62	0.190
IL-10	0.862	0.001	0.448	0.31	0.009	0.47	0.040
IL-4	0.286	0.041	0.295	0.49	0.046	0.79	0.418
MMP-9†§	0.131	0.001	0.926	0.27	0.037	0.25	0.009
ERα‡	0.045	0.149	0.389	0.89	0.711	0.62	0.074
ERβ‡	0.492	0.018	0.891	0.56	0.145	0.53	0.051

p <0.05 are in boldface.

Controlling for * nonHDLc, ^† TPC/HDLc, ^‡ TG, ^§ TPC. Main effect of menopause status and treatment on carotid gene expression was analyzed by factorial ANCOVA controlling for correlated lipid profile.