Table 4.
Hazard ratios for AKI stratified by eGFR and albuminuria categories and by hypertension status for general population cohorts.
| eGFR | No hypertension | Hypertension | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ACR/Dipstick | ACR/Dipstick | |||||||||
| <10/Dip “−” | 10–29/Dip “±” | 30–299/Dip “1+” | 300+/Dip “≥2+” | <10/Dip “−” | 10–29/Dip “±” | 30–299/Dip “1+” | 300+/Dip “≥2+” | |||
| >105 | 1.03 (0.67, 1.59) |
2.63 (1.09, 6.37) |
5.34 (2.44, 11.67) |
9.38 (3.85, 22.82) |
1.17 (0.74, 1.86) |
1.17 (0.61, 2.22) |
1.92 (0.98, 3.75) |
2.49 (1.02, 6.10) |
10.93* (4.00, 29.89) |
1.02 (0.60, 1.74) |
| 90–104 | 0.92 (0.70, 1.19) |
1.49 (0.70, 3.18) |
3.34 (1.92, 5.81) |
8.94 (6.72, 11.87) |
0.89 (0.69, 1.16) |
0.90 (0.74, 1.10) |
1.39 (1.03, 1.88) |
2.14* (1.79, 2.57) |
5.64* (3.71, 8.59) |
0.91 (0.69, 1.19) |
| 75–89 | Ref |
1.94 (1.59, 2.38) |
3.74 (3.06, 4.58) |
9.39 (7.17, 12.29) |
Ref | Ref |
1.75 (1.38, 2.22) |
2.64* (2.20, 3.17) |
4.82* (3.21, 7.23) |
Ref |
| 60–74 |
1.58 (1.42, 1.76) |
2.73 (2.22, 3.35) |
5.78 (4.74, 7.04) |
13.36 (9.13, 19.54) |
1.56 (1.43, 1.71) |
1.46 (1.34, 1.59) |
2.36 (1.81, 3.08) |
3.33* (2.56, 4.32) |
6.44* (4.66, 8.92) |
1.42 (1.29, 1.57) |
| 45–59 |
3.41 (2.87, 4.06) |
7.16 (5.42, 9.47) |
8.31 (5.73, 12.04) |
17.72 (13.77, 22.79) |
3.14 (2.57, 3.83) |
2.62* (2.03, 3.38) |
3.73* (2.84, 4.90) |
5.33 (3.65, 7.77) |
8.16* (5.34, 12.47) |
2.13* (1.77, 2.57) |
| 30–44 |
8.44 (7.08, 10.07) |
14.32 (11.02, 18.60) |
23.28 (17.67, 30.68) |
42.52 (19.10, 94.67) |
7.48 (5.87, 9.55) |
5.61* (4.24, 7.41) |
6.15* (4.13, 9.15) |
8.93* (6.77, 11.77) |
15.60 (10.23, 23.81) |
4.18* (3.62, 4.82) |
| 15–29 |
20.48 (15.51, 27.03) |
31.23 (19.51, 49.97) |
40.40 (26.37, 61.89) |
52.14 (38.05, 71.43) |
14.61 (10.52, 20.29) |
12.46 (10.08, 15.39) |
16.41* (8.11, 33.19) |
15.42* (10.48, 22.70) |
26.58* (17.35, 40.73) |
7.61* (6.43, 9.01) |
| Ref |
1.85 (1.38, 2.48) |
3.25 (2.60, 4.07) |
6.93 (5.88, 8.15) |
Ref |
1.46 (1.34, 1.60) |
2.03* (1.86, 2.23) |
3.20* (2.54, 4.03) |
|||
Hazard ratios which, compared to the reference category, are significantly (p<0.05) greater than 1 are in bold, and significant (p<0.05) interactions with hypertension are indicated with an asterisk in the hypertension subtable. Color shading indicates the strength of association (approximately one quarter of all cells are shaded in each color; Green: low; yellow: mild; orange: moderate; red: high). Units: eGFR (mL/min/1.73m2), ACR (mg/g). Abbreviations: Ref = reference group.