Table 5.
Hazard ratios for AKI stratified by eGFR and albuminuria categories and by hypertension status for CKD cohorts.
| eGFR | No hypertensive | Hypertensive | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ACR/Dipstick | ACR/Dipstick | |||||||||
| <30/Dip “−/±” | 30–299/Dip “1+” | 300–999/Dip “2+” | 1000+/Dip “≥3+” | <30/Dip “−/±” | 30–299/Dip “1+” | 300–999/Dip “2+” | 1000+/Dip “≥3+” | |||
| >75 | 0.51 (0.11, 2.26) |
0.39 (0.16, 0.92) |
1.16 (0.26, 5.20) |
0.31 (0.16, 0.63) |
0.77 (0.55, 1.08) |
0.42 (0.33, 0.54) |
0.60 (0.36, 1.00) |
4.30 (0.86, 21.66) |
0.35 (0.29, 0.42) |
|
| 60–74 | 0.71 (0.28, 1.80) |
1.80 (0.16, 20.54) |
3.55 (0.35, 36.10) |
0.75 (0.23, 2.37) |
1.28 (0.33, 4.97) |
0.93 (0.73, 1.19) |
1.06 (0.63, 1.77) |
0.68 (0.09, 4.85) |
0.64 (0.27, 1.53) |
|
| 45–59 | Ref |
1.98 (1.13, 3.45) |
3.27 (1.93, 5.54) |
5.68 (2.66, 12.11) |
Ref | Ref |
1.54 (1.32, 1.79) |
1.97 (1.56, 2.49) |
5.66 (3.33, 9.60) |
Ref |
| 30–44 |
1.93 (1.25, 2.98) |
2.43 (1.11, 5.35) |
3.43 (1.59, 7.43) |
54.62 (16.73, 178.27) |
1.50 (1.05, 2.15) |
1.45 (1.19, 1.77) |
2.21 (1.81, 2.69) |
2.60 (1.92, 3.52) |
2.61* (1.12, 6.09) |
1.36 (1.19, 1.55) |
| 15–29 |
3.81 (1.85, 7.87) |
7.75 (3.90, 15.41) |
10.41 (3.98, 27.20) |
107.42 (13.48, 856.23) |
3.55 (2.27, 5.55) |
3.68 (2.76, 4.92) |
3.86 (2.92, 5.10) |
7.05 (1.26, 39.49) |
14.79 (4.94, 44.28) |
2.61 (2.18, 3.13) |
| Ref |
1.67 (1.00, 2.77) |
2.52 (1.53, 4.17) |
5.88 (2.68, 12.93) |
Ref |
1.34 (1.20, 1.49) |
1.75 (1.31, 2.32) |
3.84 (2.19, 6.72) |
|||
Hazard ratios which, compared to the reference category, are significantly (p<0.05) greater than 1 are in bold, and significant (p<0.05) interactions with hypertension are indicated with an asterisk in the hypertension subtable. Color shading indicates the strength of association (approximately one quarter of all cells are shaded in each color; Green: low; yellow: mild; orange: moderate; red: high). Units: eGFR (mL/min/1.73m2), ACR (mg/g). Abbreviations: Ref = reference group