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. 2015 Aug 30;593(19):4387–4409. doi: 10.1113/JP270645

Figure 6. Maturation of GABAB‐modulation of sensory‐evoked inhibition in LA principal neurons .

Figure 6

A, representative IPSCs evoked by cortical fibre stimulation in juvenile and adult mice. Paired pulses were applied at an inter‐stimulus interval of 300 ms. Traces show IPSCs under control condition (left) and after application of the GABAB receptor antagonist CGP55845A (right). CGP55845A reduces paired‐pulse depression in adult mice. Scale bar: 100 pA, 100 ms. B and C, single cell and mean data showing the effect of CGP55845A application on paired‐pulse ratios of IPSCs evoked by thalamic (B) or cortical (C) fibre stimulation in the different age groups. Paired‐pulse ratios under control condition (dark grey bars) and after CGP55845A application (light grey bars). B, thalamic input. Inf: 0.69 ± 0.06 vs. 0.78 ± 0.08 (n = 17), P = 0.049; juv: 0.75 ± 0.03 vs. 0.81 ± 0.02 (25), P = 0.035; adol: 0.81 ± 0.04 vs. 0.83 ± 0.03 (19), P = 0.443; adult: 0.73 ± 0.03 vs. 0.84 ± 0.02 (23), P < 0.001). C, cortical input. Inf: 0.72 ± 0.06 vs. 0.78 ± 0.09 (n = 17), P = 0.271; juv: 0.71 ± 0.05 vs. 0.75 ± 0.05 (25), P = 0.073; adol: 0.81 ± 0.04 vs. 0.82 ± 0.04 (20), P = 0.653; adult: 0.65 ± 0.04 vs. 0.75 ± 0.04 (23), P < 0.001). P values are from paired t tests. *P < 0.05; ***P < 0.001.