Table 3.
EPSC amplitudes and paired‐pulse ratios after baclofen and baclofen+CGP55845A application
| Post hoc statistical | |||||
|---|---|---|---|---|---|
| Infant | Juvenile | Adolescent | Adult | comparisons | |
| EPSC amplitude (pA) | |||||
| Thalamic, control | −154.3 ± 16.6 (8)1 | −169.9 ± 29.3 (10)3 | −171.6 ± 23.5 (9)5 | −152.1 ± 22.9 (10)7 | 1 P < 0.001, 2 P = 0.004 |
| Thalamic, Bac | −39.3 ± 6.9 (8)1,2 | −64.1 ± 19.2 (10)3,4 | −51.4 ± 9.4 (9)5,6 | −50.1 ± 12.4 (10)7,8 | 3 P = 0.004, 4 P = 0.007 |
| Thalamic, Bac. + CGP | −150.2 ± 22.8 (8)2 | −148.4 ± 25.3 (10)4 | −143.8 ± 26.1 (9)6 | −120.3 ± 18.4 (10)8 | 5 P < 0.001, 6 P = 0.004 |
| 7 P < 0.001, 8 P < 0.001 | |||||
| Cortical, control | −99.0 ± 23.7 (7)1 | −143.9 ± 33.1 (10)3 | −162.4 ± 27.4 (9)5 | −119.2 ± 25.8 (10)7 | 1 P = 0.016, 2 P = 0.013 |
| Cortical, Bac | −27.4 ± 5.8 (7)1,2 | −50.0 ± 16.5 (10)3,4 | −53.2 ± 12.2 (9)5,6 | −56.8 ± 19.6 (10)7,8 | 3 P = 0.013, 4 P = 0.037 |
| Cortical, Bac. + CGP | −92.9 ± 20.8 (7)2 | −125.1 ± 27.9 (10)4 | −145.0 ± 24.0 (9)6 | −141.0 ± 44.2 (10)8 | 5 P = 0.002, 6 P = 0.001 |
| 7 P < 0.001, 8 P = 0.023 | |||||
| PPR | |||||
| Thalamic, control | 0.76 ± 0.03 (8)1 | 0.94 ± 0.08 (10)3 | 0.90 ± 0.05 (9)5 | 0.89 ± 0.05 (10)7 | 1 P = 0.004, 2 P = 0.003 |
| Thalamic, Bac | 1.55 ± 0.15 (8)1,2 | 1.41 ± 0.18 (10)3,4 | 1.59 ± 0.23 (9)5,6 | 1.91 ± 0.37 (10)7,8 | 3 P = 0.019, P = 0.013 |
| Thalamic, Bac. + CGP | 0.76 ± 0.04 (8)2 | 0.90 ± 0.08 (10)4 | 0.90 ± 0.06 (9)6 | 0.95 ± 0.08 (10)8 | 5 P = 0.044, 6 P = 0.032 |
| 7 P = 0.032, 8 P = 0.048 | |||||
| Cortical, control | 1.00 ± 0.19 (7)1 | 1.02 ± 0.07 (10)3 | 0.93 ± 0.09 (9)5 | 0.91 ± 0.06 (10)7 | 1 P = 0.001, 2 P = 0.001 |
| Cortical, Bac | 1.85 ± 0.26 (7)1,2 | 1.49 ± 0.11 (10)3,4 | 1.28 ± 0.09 (9)5,6 | 1.73 ± 0.22 (10)7,8 | 3 P = 0.010, 4 P < 0.001 |
| Cortical, Bac. + CGP | 1.10 ± 0.27 (7)2 | 0.87 ± 0.04 (10)4 | 0.90 ± 0.08 (9)6 | 1.10 ± 0.10 (10)8 | 5 P = 0.030, 6 P = 0.002 |
| 7 P = 0.006, 8 P = 0.026 |
Values are given as means ± SEM (number of recorded cells). EPSCs were evoked by thalamic and cortical fibre stimulation. Paired‐pulse ratios were determined at 50 ms inter‐stimulus interval. PPR, paired‐pulse ratio; Bac., baclofen; CGP, CGP55845A. Superscript numbers represent pairs of statistically significant comparisons (Bonferroni‐corrected paired t tests).