Figure 3.

Hepatic CYP2D protein levels were unchanged following exogenous testosterone administration (A) or the fluctuation of endogenous testosterone (B). Hepatic CYP2D protein was constitutively expressed in rats receiving exogenous testosterone administration at a physiological dose (1.2 mg·kg⁻¹, s.c., 7 days) or orchiectomy. In comparison with orchiectomized rats, there was no change in hepatic CYP2D protein in orchiectomized rats supplemented with testosterone at a physiological dose or supraphysiological dose (12 mg·kg⁻¹, s.c., 7 days). ORC: orchiectomy. n = 3 per group.