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. 2015 Aug 26;172(19):4639–4654. doi: 10.1111/bph.13206

Figure 4.

Figure 4

Effects of androgen deprivation on the levels of CYP2D22 mRNA and miRNAs in male growth hormone receptor deficient mice. Orchiectomy induced brain CYP2D22 mRNA (A) and decreased the levels of miR-101 and miR-128-2 (B) in the hippocampus, but no changes were observed in miR-124a or miR-125b levels. The levels of hepatic CYP2D22 mRNA (C), miR-101, miR-128-2 and miR-124a were unchanged, but miR-125b levels were decreased (D). n = 3 per group, *P < 0.05, **P < 0.01; significantly different from the sham operated group.