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. 2015 Aug 26;172(19):4639–4654. doi: 10.1111/bph.13206

Figure 6.

Figure 6

Effects of miRNAs on CYP2D6 mRNA levels in SH-SY5Y, U251 and HepG2 cells. The luciferase activity in cells transfected with the CYP2D6 3′-UTR reporter plasmid was decreased by miR-101 and miR-128-2 co-transfection (B). The predicted binding sites of miR-101 and miR-128-2 located in the 3′-UTR of the human CYP2D6, mouse CYP2D22 and rat CYP2D4/18 are shown (A). Transfection with primary miR-101 and miR-128-2 decreased CYP2D6 mRNA levels in these cells (C); however, no change in CYP2D6 mRNA was observed following the transfection of miR-124a and miR-125b. **P < 0.01, ***P < 0.001; significantly different from the respective controls.