Table 1.
IC50 values for WTC-01 against growth of a range of human cell lines
| Cancer cell lines | Normal cell line | Drug-resistant cell lines | ||||||
|---|---|---|---|---|---|---|---|---|
| Cell lines | NPC-TW01 | HONE-1 | HT-1080 | Jurkat | NCI-H226 | Detroit 551 | TW01-Taxol-Res | TW01-Met-Res |
| WTC-01 (μM) | 0.45 | 0.43 | 2.12 | 7.42 | 15.61 | >20 | 0.57 | 0.66 |
| Paclitaxel (nM) | 4.8 | 5.3 | ND | <0.6 | 0.95 | ND | 30.5 | 5.5 |
| MTX (nM) | 49.8 | 53.1 | 14.1 | 18.5 | 54.2 | >2000 | 85.6 | 2500 |
| Vincristine (nM) | 8.9 | 1.9 | ND | 130.5 | >2000 | ND | 6.3 | 14.2 |
Cancer cells were treated with various concentrations of WTC-01, paclitaxel and MTX for 72 h and cell survival was determined using an MTT colorimetric assay. Representative data from three independent experiments performed in quadruplicate are shown.