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. 2015 Aug 10;172(19):4684–4698. doi: 10.1111/bph.13242

Figure 2.

Figure 2

Arginase and p38 MAPK inhibition improve endothelium-dependent relaxation in diabetic MA. (A) Endothelium-dependent relaxation in response to ACh in MA from healthy and diabetic rats. (B, C) Effects of ABH (+ABH), SB203580 (+SB) and SB+ABH on ACh-induced relaxations of MA from healthy (B) and diabetic (C) animals. (D,E) Effect of ABH on relaxations induced by sodium nitroprusside (SNP) in healthy (D) and diabetic (E) endothelium-denuded MA. Results (means and SEM) are expressed as a percentage of the contraction induced by U46619 (n = 4–12).