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. 2015 Aug 10;172(19):4684–4698. doi: 10.1111/bph.13242

Figure 3.

Figure 3

In vivo inhibition of p38 MAPK prevents arginase-induced endothelial dysfunction and decreases arginase activity of diabetic MA. (A) Endothelium-dependent relaxations in response to ACh in mesenteric segments from DPBS-treated healthy (HS), SB203580-treated healthy (HSB), DPBS-treated diabetic (DS) and SB203580-treated diabetic (DSB) MA. (B, C) Effects of ABH on ACh-induced relaxations in MA from HS and HSB rats (B) and from DS and DSB rats (C). Data are shown as means and SEM of 8–10 arteries. (D) Arginase activity of MA from HS, HSB, DS and DSB rats. Data are shown as means and SEM of 8–10 animals. Significant differences were analysed using Student's unpaired t-test or one-way anova followed by a Bonferroni test for multiple comparisons. ***P < 0.001.