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. 2015 Aug 10;172(19):4741–4756. doi: 10.1111/bph.13248

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© 2015 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of EH-201 on SD-induced memory impairment. (A) Procedure of EH-201 treatment in SD mice. (B) Real-time PCR and (C, D) Western blot analysis of EPO expression in mouse hippocampus from each group. (E) Real-time PCR analysis of PGC-1α, haemoglobin-β and HO-1 expression levels in mouse hippocampus (n = 6). (F) The MTT assay was used as a marker for mitochondrial activity. The values depict mitochondrial function after SD of untreated control mice and EH-201-treated mice. (G) Acquisition of step-through passive avoidance during five successive training trials in mice treated with or without EH-201. EH-201 treatment did not affect learning ability in mice. (H) Acquisition of step-through passive avoidance during three successive testing trials in mice treated with or without EH-201. The values indicate the means ± SD, ^#P < 0.05, ^##P < 0.01, compared with the control: *P < 0.05, **P < 0.01, compared with the SD group; one-way anova followed by Tukey's multiple comparison test.