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letter
. 2015 Sep 4;172(19):4772–4774. doi: 10.1111/bph.12767

Figure 1.

Figure 1

Persistent current in hDAT-transfected HEK cells. Current through hDAT transiently transfected HEK293 cells. V = −60 mV, T = 37°C. 30 s of 10 μM dopamine (DA) induces an inward current that returns to baseline when dopamine is removed. 30 s of 10 μM S(+)amphetamine (S(+)AMPH) induced a similar inward peak current; however, the return of current upon wash-out of S(+)amphetamine was slower and persists for tens of seconds and up to a minute. Dopamine and S(+)amphetamine are overlaid for better comparison of kinetics. Using a mono-exponential function, we determined the time constants for the current decays: τDA = 1.3 s, τS(+)AMPH = 5.1 s, τS(+)AMPH/τDA = 3.8 s.