Table 4.
Fast inactivation time constants between −130 mV and −70 mV
| Fast inactivation time constants (ms) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Temperature | −130 mV | n | −110 mV | n | −90 mV | n | −70 mV | n | |
| Wild type | Q10 = 1.86 | Q10 = 1.92 | Q10 = 2.18 | Q10 = 4.03 | |||||
| 10°C | 18.0 ± 1.8 | 5 | 36.4 ± 5.2 | 5 | 176.0 ± 52.5 | 4 | 55.0 ± 10.0 | 4 | |
| 22°C | 5.5 ± 1.3 | 6 | 12.4 ± 2.6 | 5 | 46.5 ± 8.3 | 4 | 57.2 ± 3.1 | 5 | |
| 34°C | 3.0 ± 0.5 | 5 | 6.2 ± 0.8 | 5 | 19.9 ± 2.5 | 5 | 8.2 ± 2.1 | 5 | |
| 37°C | 2.4 | — | 5.0 | — | 15.5 | — | 5.3 | — | |
| 41°C | 1.9 | — | 3.9 | — | 11.3 | — | 3.0 | — | |
| R1193Q | Q10 | Q10 = 1.56 | Q10 = 1.71 | Q10 = 1.96 | Q10 = 2.19 | ||||
| 10°C | 15.4 ± 1.8 | 7 | 54.4 ± 6.8 | 4 | 103.2 ± 19.2 | 4 | 55.5 ± 6.2 | 4 | |
| 22°C | 4.4 ± 0.2 | 5 | 14.7 ± 4.4 | 5 | 57.2 ± 6.2 | 5 | 38.5 ± 10.5 | 5 | |
| 34°C | 3.4 ± 0.6 | 5 | 9.6 ± 2.2 | 5 | 23.7 ± 4.2 | 4 | 12.6 ± 3.0 | 4 | |
| 37°C | 2.9 | — | 7.8 | — | 19.2 | — | 9.9 | — | |
| 41°C | 2.4 | — | 6.3 | — | 14.7 | — | 7.2 | — | |
| E1784K | Q10 | Q10 = 2.27 | Q10 = 1.82 | Q10 = 1.74 | Q10 = 1.83 | ||||
| 10°C | 16.0 ± 1.8 | 5 | 25.7 ± 1.9 | 6 | 47.8 ± 7.5 | 6 | 23.8 ± 2.8 | 6 | |
| 22°C | 5.5 ± 1.5 | 5 | 8.9 ± 1.1 | 5 | 16.6 ± 2.3 | 5 | 8.3 ± 1.8 | 5 | |
| 34°C | 2.1 ± 0.3 | 5 | 4.8 ± 0.9 | 4 | 9.8 ± 2.2 | 5 | 4.5 ± 1.4 | 4 | |
| 37°C | 1.6 | — | 3.9 | — | 8.1 | — | 3.6 | — | |
| 41°C | 1.2 | — | 3.1 | — | 6.4 | — | 2.9 | — | |
Values in bold were determined by extrapolation of Q10 fits to measured values.