Table 1.
Comparative expression of PMCA transcripts in fetal and adult liver
| Species | Age | PMCA1 | PMCA2 | PMCA3 | PMCA4 | Reference |
|---|---|---|---|---|---|---|
| Human | Fetal (20–22 w) | 1b | 2 | ND | 4a | 32 |
| Human | Fetal | U | 2x | U | U | 33 |
| Human | Fetal | U | 2w | U | U | 35 |
| Human | Adult | 1b | 2w | ND | 4b | 35 |
| Human | Adult 75 y | 1x (70%) | 2x, 2w (≤1%) | ND | 4x (28%) | 25 |
| 1b (70%) | 2b (≤1%) | 4b (28%) | ||||
| Rat | Adult | 1b | 2w | ND | ND | 35 |
| Rat | 13 d | 1x > 1b | 2w | U | 4b > 4x | 15 |
| Rat | 17 d | 1x > 1b | 2w | U | 4b > 4x > 4z | 15 |
| Rat | Neonatal | 1x > 1b | 2w | U | 4b > 4x > 4z | 15 |
| Rat | Adult | 1x > 1b | 2w | U | 4b > 4a, 4d, 4x | 15 |
| Rat | Adult | H 1x, 1c | H 2A* | H 3A* | H 4a, 4d | 17 |
| KC 1x, 1c | KC 2A, 2a | KC 3A, 3e | KC 4a, 4d | |||
| HSC 1x, 1c | HSC 2A, 2a | HSC 3A, 3e | HSC 4a, 4d | |||
| Mouse | Fetal 12.5 d | Present | ND | ND | Maximal | 29 |
| Mouse | Fetal 18.5 d | Maximal | ND | ND | Minimal | 29 |
Isoforms 2A and 3A correspond to variants detected with primers designed upstream of splicing site A. Isoform 3e: HSC>
KC>H. ND; not detected; U; undetermined; HSC: Hepatic stellate cells, KC: Kupffer cells; H: Hepatocytes.