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A symmetrical pair of serotonergic PLP neurons promotes the escalation of aggression in Drosophila males. (A) 5HT-PLP neurons and their anatomical target areas, where synaptic contacts with 5HT1A receptor-bearing neurons are formed (blue ovals). CC-central complex, MB-mushroom bodies. (B) Model of the inhibitory control of aggression. An activation of the 5HT-PLP neurons releases the inhibitory input from 5HT1A receptor-bearing neurons, which leads to the escalation of aggression.
