Figure 5.

Categories and classifications of objective functions in host-pathogen models. The host-pathogen interaction pyramid is shown that integrates host, pathogen and environment to result in the diseased state phenotype. The diseased state can be queried with the correct formulation of objective functions as discussed for the three components delineated here. The two sides of the triangle represent the host and the pathogen and the connecting side represents the environment or niche. The sides converge on the vertex of the prism reflecting the lethal disease state. The space outside the host pathogen interaction prism lists objectives and their classification. Single objectives help define pathogen or host state, while multi-objectives or weighted objective functions allow definition of complex phenotypes.