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. 2014 Oct 30;7(5):e972850. doi: 10.4161/19420889.2014.972850

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — The figure depicts key signaling proteins implicated in CAV1 and Rab5 dependent cell migration. CAV1 promotes Rab5-GTP loading by sequestering p85α, which is a Rab5-GAP, leading to Rab5-dependent recruitment of Tiam1, a Rac1-GEF, to early endosomes. This cascade of events is followed by the activation of Rac1, leading to local remodeling of the actin cytoskeleton, cell migration and invasion. This mechanism is reminiscent of that previously described for Caspase‑8, which is included in the scheme to the left.