Figure 2.
Effects of MPTP on tail suspension test and forced-swimming test. (A) Tail suspension test. C57BL/6 mice with or without MPTP (25 mg/kg/d, 7 days, i.p.) were individually suspended from their tails at the height of 20 cm using a piece of adhesive tape wrapped around the tail 2 cm from the tip. Behavior was videotaped for 6 min. The values are expressed as the mean ± SEM, n = 6, *Indicates statistically significant (p < 0.05) difference from other groups at the same treatment period. (B) Forced-swimming test. C57BL/6 mice with or without MPTP treatment (25 mg/kg/d, 7 days, i.p.) were dropped individually into glass cylinders (10 × 10 cm) containing 10 cm deep water that maintained at 25 ± 1°C and remained for 6 min. The time of immobility was recorded during the last 4 min of 6-min testing period, followed 2 min of habituation. The values are expressed as the mean ± SEM, n = 5–6, *Indicates statistically significant (p < 0.05) difference from other groups at the same treatment period.