(A) Leber congenital amaurosis cohort: The average OS thickness in the central 20° was significantly shorter in nonresponders than responders (P = 0.01, t-test; equal variance, F test, P = 0.88). (B) RP cohort: The average OS thickness in central 20° was significantly shorter in nonresponders than responders (P = 0.02, Wilcoxon rank test; unequal variance, F test, P < 0.001). (C) Retinal degeneration (RD; combined): The average OS thickness in the central 20° was significantly shorter in nonresponders than responders (P < 0.001, Wilcoxon rank test) in the combined group (unequal variance, F test, P = 0.004).