Table 1.

V_j Gating Properties of Homotypic and Heterotypic Cx40-Cx43 Gap Junctions

Homotypic or Heterotypic Cx43 and Cx40 Gap Junctions
Parameter	Cx43/Cx43* −Vj	Cx43/Cx43* +Vj	Cx40/Cx40† −Vj	Cx40/Cx40† +Vj	Cx43/Cx40 −Vj (<+30)	Cx43/Cx40+Vj (>+30)
Gj,max	1.007 ± 0.002	1.057 ± 0.002	1.040 ± 0.002	1.024 ± 0.002	0.985 ± 0.002	1.111 ± 0.002
Gj,min	0.312 ± 0.002	0.270 ± 0.002	0.163 ± 0.001	0.183 ± 0.001	0.069 ± 0.002	0.253 ± 0.009
V1/2 (mV)	−60.1 ± 0.1	+56.5 ± 0.1	−48.8 ± 0.1	+48.7 ± 0.1	−35.5 ± 0.1	+89.2 ± 0.3
Valence (z)	1.82 ± 0.02	1.61 ± 0.01	3.31 ± 0.03	3.52 ± 0.03	2.10 ± 0.02	1.74 ± 0.03
r	0.97	0.97	0.97	0.97	0.94	0.98
N	7	7	6	6	7	7
Modified Heterotypic Cx43/Cx40 Gap Junctions
Parameter	50% Cx43 −Vj	50% Cx43 +Vj	50% Cx40 −Vj (<+70)	50% Cx40 +Vj (>+70)	43/40E9,13K −Vj	43/40E9,13K +Vj
Gj,max	1.072 ± 0.005	1.013 ± 0.003	1.608 ± 0.003	1.975 ± 0.047	1.014 ± 0.001	1.004 ± 0.001
Gj,min	0.128 ± 0.003	0.175 ± 0.014	−0.254 ± 0.022	1.185 ± 0.014	0.144 ± 0.003	0.341 ± 0.004
V1/2 (mV)	−48.8 ± 0.2	+87.2 ± 0.6	−0.7 ± 1.7	+107.1 ± 0.4	−40.2 ± 0.2	+46.5 ± 0.1
Valence (z)	2.06 ± 0.03	1.58 ± 0.04	−0.50 ± 0.02	5.23 ± 0.30	2.04 ± 0.02	3.98 ± 0.06
r	0.93	0.95	0.90	0.98	0.97	0.98
N	6	6	6	6	3	3

All parameter values are the fitted mean ± s.d.

^*Homotypic Cx43 V_j gating parameters are from Lin et al.²²

^†Homotypic Cx40 V_j gating parameters are from Lin et al.²³