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. 2014 Oct 30;8(6):519–527. doi: 10.4161/19336950.2014.967623

Figure 7.

Figure 7.

Summary of effects of signaling pathway modulators administered with L-803,087. L-803 reduced ICa in isolated RGCs (n = 27; 41.2 +/− 2.7% vs. control). Pre-treatment with pertussis toxin (PTX) had no effect on the L-803-mediated calcium channel current reduction (n = 10; 34.7 +/− 3.8%). The non-selective PKC antagonist, GF109203X had a concentration dependent effect on L-803-mediated current reduction (1 μM: n = 11; 34.3 +/− 4.4%; 5 μM: n = 8; 14.6 +/− 3.2%; *P < 0.05 vs. L-803 alone). Pre-treatment of cells with anti-β gamma (Anti-Gßγ) peptide impaired the ability of L-803 to reduce calcium channel current (n = 10; 23.0 +/− 4.8%; *P < 0.05 ANOVA vs. L-803 alone). Combination treatment with 5 μM GFX and Anti-Gßγ peptide abolished the effects of L-803 (n = 6; 1.8 +/− 6.0%; *P < 0.05 ANOVA vs. L-803 alone).