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. 2014 Oct 16;9(4):265–276. doi: 10.4161/19336918.2014.972761

Figure 2.

Figure 2.

Non-cell autonomous interactions can increase metastatic propensity: exosomes as an example. The BL6–10 cell line is a highly metastatic subclone derived from the non-metastatic F1 cell line. Met 72, a previously identified metastasis marker, was found to be expressed on the surface of (A) BL6–10 cells, but not (B) F1 cells. Additionally, Met 72 was expressed on the surface of exosomes derived from BL6–10 cells. (C) Treating F1 cells with exosomes from BL6–10 cells caused F1 cells to become Met 72-positive and significantly increased the metastatic ability of F1 cells.83