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. 2015 Feb 9;9(1):21–29. doi: 10.4161/19336950.2014.978676

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© 2015 The Author(s) Published with license by Taylor & Francis Group, LLC

© Jaime S Horton, Clay T Wakano, Mark Speck, and Alexander J Stokes

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 6. — Proposed model of TPC1 involvement in cytokinesis. TPC1 overexpression causes an imbalance in autophagy, dysregulation of spatial and/or temporal localization of CIT, affecting proper RhoA localization at the midbody and abscission failure. In WT cells with tightly controlled TPC1 expression, TPC1 likely helps to maintain RhoA homeostasis through normal turnover via lysosomal autophagy. The scaffold protein CIT directs RhoA localization to the midbody for abscission and cytokinesis completion.