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. 2015 Aug 7;21(6):748–761. doi: 10.1093/humupd/dmv038

Figure 3.

Figure 3

Endometrial coagulation pathways. Immediate: A platelet plug forms rapidly, relying on interactions with tissue factor, vWF and collagen. Subsequent: intrinsic and/or extrinsic activation of coagulation pathways result in formation of a fibrin clot to ensure haemostasis. Fibrinolysis drives the degradation of the fibrin clot. t-PA and u-PA convert plasminogen to plasmin, which breaks down the fibrin clot. PAI converts plasmin back to plasminogen.