TABLE 2 ] .

Liver Pathology in Telomere Syndrome Cases With Hypoxia and Shunting (n = 6)

Age at Biopsy, y	Parenchyma	Vasculature	Iron Accumulation	Fibrosis	Case No.a
17	…	Telengiectasia	None	None	1
25	NRH, minimal portal chronic inflammationb	Normal	Moderate in hepatocytesb	None	4c
34	NRH, early mild steatosisb	Prominent portal vesselsb	None	None	6c
40	NRH, bile duct paucity, diffuse cholestasis, noncaseating granulomasb	Prominent portal vesselsb	Mild in hepatocytes and periportalb	Minimal patchy-portal and periportal	7c
52	Normal	Sinusoidal dilatationb	None	None	8
53	NRH, chronic inflammatory infiltrateb	Some portal areas without veinsb	Mild in hepatocytes and periportalb	None	9c

NRH = nodular regenerative hyperplasia.

^aCase identifiers refer to Table 1.

^bA recurrent abnormality shared by two or more cases.

^cThese biopsies/explants were reviewed centrally as part of this study.