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. 2015 Apr 15;6(18):16198–16214. doi: 10.18632/oncotarget.3838

Figure 2. Lactate upregulated the expression of MCT1 in THP-1 monocytes.

Figure 2

A-D. The protein expressions of MCT1 and MCT4 in THP-1 monocytes stimulated with lactate A., cultured alone B., cultured in CM C., or co-cultured with HCT116 cells D. were measured. Protein bands were quantified. E-H. THP-1 monocytes were treated with 10 mM lactate without or in the presence of PCMB for 12 h. MCT1 protein expression E., and the quantities of lactate F., glucose G., and PGE2 H. in the supernatant were measured. I, J. THP-1 monocytes were stimulated with the condition medium and/or PCMB for 12 h. Glucose I. and PGE2 J. in the supernatant were measured. Bars, SD; *p < 0.05 or **p < 0.01 versus untreated controls.