Table 1.
Disposition and demographics
| Demographics | Healthy | Severe renal impairment |
|---|---|---|
| Age (years), mean (SD) | 56.8 (6.71) | 62.5 (9.87) |
| Gender n (%) | ||
| Female | 2 (25) | 2 (25) |
| Male | 6 (75) | 6 (75) |
| BMI (kg m–2), mean (SD) | 25.70 (3.45) | 27.28 (4.71) |
| Height (cm), mean (SD) | 174.9 (5.72) | 171.4 (6.44) |
| Weight (kg), mean (SD) | 78.96 (13.99) | 80.36 (15.48) |
| Ethnicity, n (%) | ||
| Hispanic or Latino | 1 (12.5) | 0 |
| Not Hispanic or Latino | 7 (87.5) | 8 (100) |
| Race, n (%) | ||
| African American/African heritage | 2 (25) | 2 (25) |
| African American/African heritage and White | 1 (12.5) | 0 |
| White – White/Caucasian/European heritage | 5 (62.5) | 6 (75) |
| Renal function* (ml min–1), mean (SD) | 115 (19) | 20 (4) |
| Albumin (g l–1), mean (SD) | 40.9 (4.5) | 40.3 (4.6) |
SD, standard deviation; BMI, body mass index.
*
As assessed by estimated creatinine clearance using Cockcroft-Gault equation in healthy subjects or estimated GFR using the MDRD equation in severely renally impaired subjects.