Table 3.

Risk factors correlated with adverse reactions in adult patients

Reference	Demography					Correlation with risk factors
	Patients (n)	Serious ARs or hospitalizations (n)	ARs (%)	Gender		Age		Number of drugs		Co-morbidities		Impaired renal function
ARs during and/or causing hospitalization:
Bordet et al. 8	16 916	86	0.5			O
Fattinger et al. 6	3624	144	4	F		No		No
Cabello et al. 3	289	17	5.9	No		No		F		No
Darchy et al. 7	623	41	6.6	F		O		Yes
Moore et al. 9	329	31	9.4	F		O		Yes
Buajordet et al. 4	732	133	18.2	No		M		Yes		Yes
ARs causing hospitalization:
Caranasos et al. 30	6063	177	2.9	F		O
Pouyanne et al. 18	3137	100	3.2	F		O
Onder et al. 15	28 411	964	3.4			O				Yes
Hallas et al. 23	366	15	4.1	No		O		No
Levy et al. 29	5432	270	5	F		No		Yes				Yes
Leendertse et al. 13	12 793	714	5.6	No		O		Yes		Yes		Yes
Hermesh et al. 26	321	24	7.5			O
Hallas et al. 20	1999	157	7.9	F		O		Yes
Colt et al. 24	244	23	9.4	No				Yes		No
Bergman et al. 27	285	31	10.9	F		No		Yes
Davidsen et al. 25	426	49	11.5					Yes
Mjörndal et al. 14	681	99	14.5	No		No		Yes
Santamaria-Pablos et al. 10	163	27	16.6	No		Y		No		No
Mean	4360	163	3.7
	Risk factor (yes/no)			No	Yes	No	Yes	No	Yes	No	Yes	No	Yes
	Univariate analysis (number of studies)			7	8 (F)	5	10 (O)	3	10	3	3	0	2
							1 (M)		1 (F)
				1 (Y)				1
	Multivariate analysis (number of studies)			2	1 (F)	3	1 (O)	1	3
							1 (Y)

F, Female; M, Male; O, correlation with older patients; Y, correlation with younger patients.