Table 4.

Risk factors correlated with adverse reactions in elderly patients only

Reference	Demography				Correlation to risk factors
	Patients (n)	Age (years) (mean)	Serious ARs or hospitalizations (n)	ARs (%)	Gender	Age	Number of drugs	Co-morbidities	Impaired renal function
Malhotra et al. 16	578	72.5	39	6.7	No
Wawruch et al. 11	600	76.6	47	7.8	No	≥75	≥6	≥4	No
Hallas et al. 21	294	81	33	11.2	No	No	No
Helldén et al. 12	153	82.1	22	14.4	No	F	No		F
Col et al. 22	315	76.6	53	16.8			Yes
Cooper et al. 19	332	82	64	19.3	No	No	Yes
Mannesse et al. 17	106	78	25	23.6	No		≥3	≥5
Mean	340	78.4	40.4	11.9
				Multivariate analysis
				Reference	Gender	Age	Number of drugs	Co-morbidities	Impaired renal function
				Wawruch et al. 11
				Malhotra et al. 16			≥3
				Mannesse et al. 17			≥3	No
				Hallas et al. 21	No	No	No
				Col et al. 22			>3