Table 1.
Characteristics of patients whose deaths were considered ADR-related, vs. patients whose deaths were not considered ADR-related
| All deaths | ADR-related deaths | Other deaths | P value | |
|---|---|---|---|---|
| All patients: n | 357 | 56 | 301 | |
| Females: n (%) | 184 (52%) | 30 (54%) | 154 (51%) | P = 0.741 |
| Age (years): median [IQR] | 53 [38, 70] | 52.5 [33, 65.5] | 53 [39, 72] | P = 0.2209 |
| Known HIV infected (%) | 135 (38%) | 31 (55%) | 104 (35%) | P = 0.003 |
| On treatment for TB (%) | 55 (15%) | 14 (25%) | 41 (14%) | P = 0.030 |
| Number of drugs exposed to: median [IQR] | 7 [5, 11] | 9 [7, 11] | 7 [4, 11] | P = 0.0008 |
| Modified Charlson co-morbidity score: median [IQR] | 2 [0, 3] | 2 [1, 3] | 2 [0, 3] | P = 0.0246 |
| Time from admission to death (days): median [IQR] | 5 [3, 10] | 6.5 [3, 11.5] | 5 [3, 10] | P = 0.3478 |
| HIV-infected patients only: n | 135 | 31 | 104 | |
| Females: n (%) | 61 (45%) | 15 (48%) | 46 (44%) | P = 0.683 |
| Age (years): median [IQR] | 37 [30, 44] | 37 [31, 52] | 37 [30, 43] | P = 0.3393 |
| CD4-count (cells mm−3): median [IQR]* | 52 [19, 167] | 126 [32, 299] | 41 [19, 109] | P = 0.0509 |
| On ART (%) | 66 (49%) | 20 (65%) | 46 (44%) | P = 0.047 |
| On treatment for TB (%) | 45 (33%) | 12 (39%) | 33 (32%) | P = 0.469 |
| Number of drugs exposed to: median [IQR] | 9 [6, 12] | 9 [7, 10] | 9 [6, 12] | P = 0.8053 |
| Modified Charlson co-morbidity score: median [IQR] | 0 [0, 2] | 2 [0, 2] | 0 [0, 2] | P = 0.0579 |
| Time from admission to death (days): median [IQR] | 5 [3, 8] | 4 [2, 7] | 5.5 [3, 8.5] | P = 0.2082 |
*
20 patients missing data. ADR, adverse drug reaction; ART, antiretroviral therapy; HIV, human immunodeficiency virus; IQR, interquartile range; TB, tuberculosis.