Table 3.
Multivariate logistic regression model for the association between risk factors and ADR-related death (n = 357)
| Variable | Patients, n (%) | Crude odds ratio (95% confidence interval) | Adjusted odds ratio (95% confidence interval) | Wald test P value |
|---|---|---|---|---|
| Sex | 357 | |||
| Male | 173 (48%) | 1 | 1 | |
| Female | 184 (52%) | 1.1 (0.62, 2.0) | 1.2 (0.64, 2.2) | 0.581 |
| Age* | 357 | 0.91 (0.78, 1.1) | 1.1 (0.83, 1.3) | 0.644 |
| HIV group | 357 | |||
| HIV serology negative or unknown | 222 (62%) | 1 | 1 | |
| HIV-infected and not on ART | 69 (19%) | 1.5 (0.69, 3.2) | 2.4 (0.78, 7.1) | 0.127 |
| HIV-infected and on ART | 66 (18%) | 3.4 (1.8, 6.7) | 4.4 (1.6, 12) | 0.003 |
| TB infection status | 357 | |||
| Not on treatment for TB | 302 (85%) | 1 | 1 | |
| On treatment for TB | 55 (15%) | 2.1 (1.1, 4.2) | 1.2 (0.53, 2.6) | 0.689 |
| Drug count | 357 | |||
| ≤7 drugs | 181 (51%) | 1 | 1 | |
| >7 drugs | 176 (49%) | 3.4 (1.8, 6.3) | 2.5 (1.3, 4.8) | 0.009 |
| Modified Charlson comorbidity score† | 357 | 1.2 (1.0, 1.5) | 1.3 (1.1, 1.7) | 0.009 |
*
Included in the model as a continuous variable. The odds ratio is for a 10 year increase in age. †The odds ratio is for a one unit increase in the comorbidity score. ADR, adverse drug reaction; ART, antiretroviral therapy; TB, tuberculosis.