Table 4.
Multivariate logistic regression model for the association between risk factors and ADR-related death in HIV-infected persons (n = 115)
| Variable | Patients, n (%) | Crude odds ratio (95% confidence interval) | Adjusted odds ratio (95% confidence interval) | Wald test P value |
|---|---|---|---|---|
| Sex | 115 | |||
| Male | 61 (53%) | 1 | 1 | |
| Female | 54 (47%) | 1.4 (0.59, 3.4) | 1.2 (0.47, 3.2) | 0.664 |
| Age* | 115 | 1.3 (0.88, 2.0) | 1.3 (0.80, 2.0) | 0.305 |
| CD4-count† | 115 | 1.1 (1.0, 1.3) | 1.1 (0.98, 1.3) | 0.088 |
| Antiretroviral therapy | 115 | |||
| Not on ART | 58 (50%) | 1 | 1 | |
| On ART | 57 (50%) | 2.9 (1.1, 7.3) | 2.4 (0.86, 6.6) | 0.096 |
| TB infection status | 115 | |||
| Not on treatment for TB | 75 (65%) | 1 | 1 | |
| On treatment for TB | 40 (35%) | 1.5 (0.62, 3.7) | 1.1 (0.42, 3.1) | 0.802 |
| Drug count | 115 | |||
| ≤7 drugs | 41 (36%) | 1 | 1 | |
| >7 drugs | 74 (64%) | 3.9 (1.2, 12) | 3.6 (1.1, 12) | 0.041 |
| Modified Charlson comorbidity score‡ | 115 | 1.3 (0.95, 1.9) | 1.2 (0.84, 1.8) | 0.281 |
*
Included in the model as a continuous variable. The odds ratio is for a 10 year increase in age. †Included in the model as a continuous variable. The odds ratio is for an increase of 50 cells mm–3. ‡The odds ratio is for a one unit increase in the comorbidity score. ADR, adverse drug reaction; ART, antiretroviral therapy; TB, tuberculosis.