Table 2.
Studies evaluating quality of life in children with adverse drug reactions
| Study, country | Drug involved | Study design | Population studied | HRQL/QoL instrument | Main findings |
|---|---|---|---|---|---|
| Rabbett et al. (1996), England [34] | Not specified | Randomized cross-sectional study | 16 children aged 8–17 years with Crohn’s disease | Rutter A Questionnaire | Side-effects of treatment are the parents’ main concern regarding their children’s QoL. Adverse drug reactions were associated with lower QoL |
| Iorio et al. (1997), Italy [35] | α-Interferon | Prospective cohort | 94 children aged 3–14 years with chronic viral hepatitis | Modified sickness impact profile | Health-related quality of life deteriorated significantly during α-interferon therapy |
| Bellaire et al. (2005), Canada [18] | Miscellaneous | Retrospective cohort | 42 children aged 5–17 years with one ADR vs. multiple ADRs | Parent-Form 50 (CHQ-PF50) | Children with multiple ADRs had a lower HRQL than children with one ADR |
| Morita et al. (2007), USA [25] | Carbamazepine and valproic acid | Prospective cohort | 37 children of mean age 7.2 years with new-onset epilepsy | PedsQL and USQOLCE | Severe ADR/side-effects were inversely related to QoL |
| Virag et al. (2010), Slovakia [36] | Carbamazepine and valproic acid and others | Retrospective, prospective cohort | 293 children with epilepsy (mean age 12.9 years) | QOLIE-AD-48 (Slovak version) | Adverse effects of antiepileptilc drugs correlated with QoL |
| Modi et al. (2011), USA [26] | Carbamazepine and valproic acid | Longitudinal prospective study | 124 children aged 2–12 years with newly diagnosed epilepsy | PedsQL | Side-effects from anticonvulsants were negatively associated with all HRQL domains |
| Arslan et al. (2013), Turkey [37] | Various chemotherapeutic agents | Cross-sectional study | 93 children aged 10–18 years with leukaemia, lymphoma or solid tumours | PedsQL 4.0 | The occurrence of chemotherapy-related symptoms/side-effects was associated with lower QoL |
| Erickson et al. (2011), USA [38] | Various chemotherapeutic agents | Prospective cohort | 20 children aged 12–19 years with leukaemia, lymphoma or solid tumours | PedsQL | Occurrence of chemotherapy-related fatigue was associated with lower QoL |
| Lara-Herguedas et al. (2011, 2013), Spain [39], [40] | Miscellaneous | Observational, cross-sectional, multicentre study | 550 children aged <18 years with epilepsy | Quality of life scale CAVE and modified LAEP | Adverse effects of antiepileptics were inversely associated with QoL |
Abbreviations are as follows: ADR, adverse drug reaction; CAVE, Quality of Life scale in childhood epilepsy; CHQ-PF50, Child Health Questionnaire; HRQL, health-related quality of life; LAEP, Liverpool Adverse Events Profile; PedsQL, Pediatric Quality of Life Inventory; QoL, quality of life; QOLIE-AD-48, Quality Of Life In Epilepsy for Adolescents; USQOLCE, American Quality of Life in Childhood Epilepsy Questionnaire.