Table 5.

Reasons why it may be appropriate to perform volumetric studies on hippocampus or other potentially epileptogenic areas

Rationale for volumetric analysis
➢ To establish normative date
● Breed and size variations
● Age
● Gender
● Within subject functional and anatomical asymmetry [75]
➢ To provide a baseline
● At initial diagnosis and for serial comparison, for example, if develops drug-resistant epilepsy
➢ To identify patients with poor prognosis / less likely to respond to treatment
● Volume compared to normative data
● Within subject asymmetry in volume
➢ Improving cohort selection for entry into clinical trials evaluating
● Antiepileptic drugs
● Neuro-protective agents that may modulate the consequences of epilepsy on cognition and behaviour [76]
● Novel treatment modalities